DVT More Likely With Varicose Veins
In the latest study, the Taiwanese researchers note the association between varicose veins and PAD remained after controlling for hypertension, diabetes, COPD, hyperlipidemia and malignancy, "suggesting that the increased risk of PAD could not be attributed exclusively to these confounders".
People with varicose veins may need to be monitored more closely, the researchers recommended in the study, in order to determine if there is a more serious health risk involved.
"Varicose veins really only affect the superficial venous system, not the deep venous system", he said, noting that people with the condition typically have normal blood flow in the deep venous system without slowing or reversal of flow. "Due to the strong relationship between varicose veins and the increased risk of more serious disease, patients with varicose veins deserve careful monitoring and early evaluation".
In addition, the researchers found higher risks for pulmonary embolisms and peripheral artery disease in patients with varicose veins, though these findings were less clear due to some factors in the study. This translates to 6.55 per 1,000 person-years versus 1.23 per 1,000 person-years.
They suggest one possible explanation is that people with varicose veins have increased levels of inflammation or blood clotting abnormalities.
In any case, they trust irritation in the veins are presumably included, whichever the reason.
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The condition is quite common, so much so that as many as 23 per cent of America's adult population are said to be living with varicose veins.
The study suggests that varicose veins should be taken more seriously and likely treated more aggressively, she said.
What recommendations do you have for future research as a result of this work?
Those studies were cross-sectional or case-control studies, had small sample sizes, and didn't verify the diagnosis of varicose veins, according to the study authors, led by Pei-Chun Chen, PhD, of the Department of Public Health at China Medical University.
Inflammation has become "increasingly recognized as a key player in the development of vascular disease, including deep venous thrombosis, pulmonary embolism, stroke and heart attack", Piazza said. More research is needed since the study did not prove that varicose veins cause the clots, he said. To better understand the "intricate" genesis of these diseases, "more research is needed".
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