Edinson Cavani in action for Uruguay against the Czech Republic
Ryan Giggs kept faith with the side which thrashed China 6-0 in their semi-final, meaning Gareth Bale was set to win his 70th cap and skipper Ashley Williams his 78th.
Dan Fitch is expecting a low-scoring draw when Wales take on Uruguay in the China Cup final on Monday lunchtime.
The final will be the first time Wales and Uruguay have met since a friendly in 1986.
Wales' previous record goalscorer Ian Rush started up front for Wales that day in a match played at the Racecourse Ground, Wrexham.
It took less than two minutes for Suarez's threat to become obvious.
Cavani's finish was enough to seal the win for Uruguay, and the China Cup will be going back to South America with them - could it soon be joined by the World Cup?
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The Barcelona forward again struck the woodwork in the 31st minute after latching onto a sloppy Wales back-pass and rounding goalkeeper Wayne Hennessey.
Wales responded with a long-range Bale effort before Sam Vokes worked Fernando Muslera following an excellent Harry Wilson cross. The right-hand post denied him on this occasion.
Uruguay found the breakthrough in simple and clinical fashion, punishing their opponents' lacklustre resumption after half-time.
A similarly straightforward chance should have seen Cavani put the result beyond doubt four minutes later, but the Paris Saint-Germain star misjudged a centre with a touch more pace from Guillermo Varela.
- Ashley Williams made his 78th worldwide appearance for Wales - he is now level with Craig Bellamy - the only outfield players to have more caps are Gary Speed (85) and Chris Gunter (87).
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