The talented French midfielder - signed for a club record £89m in 2016 - was hauled off in the 58th minute of Sunday's shock 1-0 defeat at home to West Brom. Anthony Martial, Matteo Darmian and Daley Blind are also set to be offloaded.
The FA Cup is the final opportunity for both sides to pick up silverware this season, having both gone out of the Champions League at the last 16 stage while Manchester City have already claimed the Premier League and Carabao Cup double. This is a huge risk though.
"The way you play is the only way I can select players", said Mourinho. De Bruyne, Salah, anyone?
The 25-year-old Brazilian has played 32 times for his side this season, scoring four goals and assisting a further five strikes.
Meanwhile, Manchester United are now preparing for their Premier League clash against Bournemouth on Wednesday night.
"So it is not rotating, because rotating looks like a player that plays against Bournemouth is to give a rest to somebody that is going to play against Spurs in the semi-final".
The comment will likely divide Manchester United fans, many of whom seem unable to agree on whether either Pogba or Sanchez actually deserve to be in the team, or are just being selected based on reputation and the size of their wage packet.
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Stocks Taking a Gut Shot: Edison International (EIX), Ecopetrol SA (EC)
It generates electricity through hydroelectric, diesel/liquid petroleum gas, natural gas, nuclear, and photovoltaic sources. The Average Earnings Estimate for the Current Fiscal quarter is $0.94 per share, according to consensus of 9 analysts.
Manchester United manager Jose Mourinho has indicated he is prepared to drop first-team regulars over issues with form ahead of the trip to Wembley on Saturday.
"I don't think we will see seven or eight players leave or seven or eight players coming in".
"It is an opportunity for some people to play and to try and get a place in the team for the Spurs".
"Or do you want me to go for the price they cost, or their salary, or their lovely face? The only way is to go with performance".
But now The Sun report that, in the middle of Pogba's heroics, his relationship with Mourinho actually took another knock when they clashed during half-time.
The former Real Madrid manager has managed some other top clubs and has led them to league triumphs except United, which he will be hoping to do next term. One trophy, FA Cup final.
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