Takeda's initial bid priced Shire at £44 (nearly $63) per share, consisting of £28 (about $40) per share in new Takeda shares, to be listed in Japan and in the US through an American Depositary Shares listing, and £16 (about $23) per share cash.
Vitamins made by Shire are displayed at a chemist's in northwest London, Britain, July 11, 2014.
Second proposal-A total £45.50 (about $65) per share, consisting of £28.75 (nearly $41) per share in new Takeda shares, to be listed in Japan and in the US through an ADR listing, and £16.75 (about $24) per share cash.
It would be Weber's boldest move by far, significantly expanding the company's US presence while boosting its position in rare diseases, gastrointestinal disorders and neuroscience, where Shire is a leader in drugs to treat hyperactivity.
Buying Shire would be transformational for Takeda but would be a big financial stretch, since the company is worth in excess of $10 billion more than the Japanese group.
Takeda's reported offer comes amid a flurry of transactions in the pharmaceutical sector, marked by GlaxoSmithKline Plc's $13 billion agreement last month to buy out Novartis AG's stake in the two companies' consumer-health joint venture.
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That offer was rejected by Shire's board as directors said it "significantly undervalued the company, its growth prospects and pipeline".
Shire also rejected the third proposal, made up of £17.75 in cash, to be paid in U.S. dollars, and £28.75 of new Takeda shares. That would value Shire at approximately 43 billion pounds, or $61 billion, Thomson Reuters data showed. The first valued Shire at up to £44.00 per share, the second was £45.60 and the third was £46.50.
The UK's Shire has said it has rejected a bid of around £42 billion, around $60 billion, from Takeda, but is in talks with the Japanese firm's advisers to secure a better deal.
In reaction, Shire's shares jumped 8% to £40.70 each in London afternoon trading.
A bidding war for Shire is threatening to break out after Botox maker Allergan said it was considering a takeover offer for the rare diseases drug maker.
This week Shire said it was selling its cancer treatment unit to France's Servier for £1.7bn in a deal that was initiated in December and was unrelated to the possibility of a takeover bid.
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