The win for Saints also condemned West Brom who join Stoke as relegated, this on the day that their manager Darren Moore was given the Premier League manager of the month award.
The club's booking at the Marriott hotel, Swansea, was cancelled after the discovery of what Public Health Wales called a "potential infectious disease incident".
Swansea's manager Carlos Carvalhal can only hopes the champions have one more exceptional 90 minutes in them.
Southampton have now taken seven points from their past three games and Hughes felt the pre-match row over Southampton's cancelled Swansea hotel booking had worked in their favour.
"That helped our focus and we won't be staying in the vicinity of the hotel Marriott Swansea - I think we will stick to the Vale of Glamorgan".
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"We weren't going to be denied and messed about".
The win saw the Saints climb three points clear of the relegation zone and left Swansea three points from safety with each having one game remaining. The odds will be on our side but it is football and they are Man City.
Substitute Manolo Gabbiadini scored after 72 minutes and the winning goal means Mark Hughes's team are nearly safe as they have a superior goal difference over relegation rivals Huddersfield Town and Swansea. "It's not done mathematically but we've put ourselves in a good position", Hughes said.
Reflecting on the recent Bournemouth defeat, Carvalhal said to Sky Sports: "After a game that we lose, everyone is sad of course, but we will react and Tuesday, we must be at the top".
"We suspected that maybe some of the dark arts were at work but we didn't let it affect us". The problem being those two games are against Chelsea away on Wednesday night and then Arsenal at home on Sunday. We don't know what will happen tomorrow and at the weekend we must try and do our part and try to win.
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