Northern Ireland Secretary James Brokenshire has quit the cabinet ahead of a reshuffle. The politician said he is expected to undergo surgery to remove a lung lesion.
Mr Brokenshire played a vital role in resolving the crisis last month that threatened to destroy hopes of a deal on the terms of the UK's withdrawal from the European Union. The minister has been in charge of settling a political crisis that has been raging in the semi-autonomous province of the United Kingdom for nearly a year.
However, she will now have to appoint a successor for Mr Brokenshire.
The failure of the talks is pushing Northern Ireland closer towards direct rule from London. She paid tribute to his "diligence, determination and good humour", and said she looked forward to working with him again when he is better.
The Northern Ireland Office confirmed his resignation, but gave no further details.
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He resigned from the Cabinet in January 2018 as Theresa May carried out a sweeping reshuffle of ministers - but why did he step down?
He was elected at the 2005 general election to the now dissolved constituency of Hornchurch'.
However, Education Secretary Justine Greening, Conservative Party chairman Sir Patrick McLoughlin, Business Secretary Greg Clark and the Leader of the Commons Andrea Leadsom are among those reported to be vulnerable.
Previously, he was a Minister at the Home Office, consecutively taking on the Crime Prevention, Security and Immigration briefs.
Shadow health secretary Jon Ashworth said yesterday: "If she promotes this Health Secretary tomorrow it's a betrayal of those 75,000 people in the back of ambulances".
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