Lukaku, United's leading scorer in the league with 16, sustained an ankle injury in last month's victory over Arsenal and travelled back to Belgium to recover.
The 25-year-old made a decision to undergo his rehabilitation in Brussels but the prolific forward is now back in England for training.
United boss Jose Mourinho is planning a significant overhaul of his defensive options this summer, with the left-back slot understood to be one of his main priorities after Ashley Young established himself as the first choice in that position this season.
The French forward is also a fitness concern for Mourinho, who confirmed he picked up a knee injury before the game against Watford.
"It has played on my mind a little bit, but there's nothing I can do about it".
Hadary on way to being oldest World Cup player
Cuper gave first-time call-ups to Tarek, defender Mahmdoud Hamdy, midfielder Mahmoud Abdel-Aziz, and forward Ahmed Gomaa. The team will play in Group A along with host Russia, Saudi Arabia and Uruguay. "The journey is hard ".
Graves: Current formats not attracting audiences
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However, the French global was omitted from the squad to face the Hornets at Old Trafford and Mourinho has confirmed the attacker picked up a knee injury in training on Friday.
"He was injured in the Friday training session, yesterday he could not train".
"I'm waiting for the doctor but when it's impossible to play today, I have my doubts (for the Cup final)".
"Now I am used to it, I know what to expect".
But despite these issues, De Gea recently stated he wants someone else to win Manchester United's Player of the Year award next season instead of him, hinting perhaps he is set to stay.
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